Matrix-metalloproteinase-9 is cleaved and activated by Cathepsin K

Expression of Matrix Metalloproteinase-2 and -9 in Meningioma

Background: Meningioma is one of the most common tumors of the central nervous system. It was shown that meningioma had up-regulated expression of Matrix Metalloproteinases (MMPs) that involved in cell growth, angiogenesis and metastasis.  Objectives: The aim of the study was the assessment of serum MMP-2 and -9 levels in patients with different grades of meningioma.  Materials & Me...

Gene Polymorphism of Matrix Metalloproteinase 9 in Asthenozoospermic Male Subjects

Objective Matrix Metalloproteinase (MMPs) play important roles in the structural and functional properties of reproductive organs. The aim of this study is to determine the prevalence of C-1562T Matrix Metalloproteinase-9 (rs3918242) gene polymorphism in fertile and infertile men. In addition, we aimed to determine the association between C-1562T MMP-9 and G-1575A MMP-2 gene polymorphisms. Mate...

Substrate Hydrolysis by Matrix Metalloproteinase - 9 Steven

Cathepsin and calpain inhibitor E64d attenuates matrix metalloproteinase-9 activity after focal cerebral ischemia in rats.

BACKGROUND AND PURPOSE Matrix metalloproteinases (MMPs) and cysteine proteases (calpain and cathepsin B) play an important role in cell death and are upregulated after focal cerebral ischemia. Because there is a significant interaction between MMP-9 with calpain and cathepsin B, we investigated the role of E64d (a calpain and cathepsin B inhibitor) on MMP-9 activation in the rat focal ischemia ...

Plasma matrix metalloproteinase-9 level is better than serum matrix metalloproteinase-9 level to predict gastric cancer evolution.

PURPOSE Matrix metalloproteinase-9 (MMP-9) in blood is a promising new tumor marker. The aims of the present study are to compare the usefulness of plasma and serum MMP-9 levels for predicting gastric cancer development, invasion, and survival. EXPERIMENTAL DESIGN In this nested case-control study, 114 gastric cancer patients and 87 healthy controls were enrolled. MMP-9 levels and activities ...